Endocrine Abstracts

Background: Endothelial dysfunction may have deleterious effect cardiovascular pathology in diabetic patients.Atrial natriuretic peptide (ANP) exerts beneficial effects on the cardiovascular system in part by exerting antioxidant activity. Recently it was reported that ANP is able to exert an antihypertrophic effect in myocitos at least in part due to inhibition of NADPH oxidase and superoxido generation.It seems that hyperglucemia...

Aim: To assess ET1 levels in diabetic patients with and without microangiopathy, and compared with normal subjects, nondiabetic, without underlying vascular pathology.Introduction: The pathophysiology of diabetic microangiopathy is complex and many important aspects of it still are not fully understood. Endothelial dysfunction is of major importance in the pathogenesis of atherosclerosis and diabetic angiopathy. ET-1 is one of the most potent vasoconstri...